Maximizing the potency of oxaliplatin coated nanoparticles with folic acid for modulating tumor progression in colorectal cancer

One of the challenges nanotechnology is to improve efficacy treatments for diseases, in order reduce morbidity and mortality rates. Following this line study, we made a nanoparticle formulation with small size, uniform surfaces, satisfactory encapsulation coefficient as target colorectal cancer cells. The results binding uptake prove that using system folic acid works: Using system, cytotoxicity cell death are increased when compared free oxaliplatin. data show maximized efficiency oxaliplatin modulating tumor progression, increasing apoptosis decreasing resistance drug. Thus, first time, our findings suggest PLGA-PEG-FA increases antitumor effectiveness by functioning facilitator drug delivery cancer.